The name Isidro has its origins in the Spanish language, derived from the Late Latin name Isidorus, which itself comes from the Greek name Isidoros. This name is composed of the elements "isis" meaning "gift" and "doron" meaning "gift." The name was initially associated with the ancient Greek island of Chios.

One of the earliest and most famous bearers of the name was Saint Isidore of Seville, a scholar and author who lived from 560 to 636 AD. He was a notable figure in the Catholic Church and is considered the last scholar of the ancient world. His most famous work, the Etymologiae, was an encyclopedic collection of knowledge.

Another notable figure was Isidro Labrador, a Spanish farmworker who lived from 1070 to 1130 AD. He is revered as the patron saint of farmers and rural communities in Spain. His life and work in the fields of Madrid were marked by his deep religious devotion and charity towards the poor.

In the 16th century, Isidro de Hinojosa (1493-1557) was a Spanish mystic and Franciscan friar. He is known for his writings on spiritual topics and his role in the reform of the Franciscan Order.

During the Spanish Golden Age, Isidro de Novia (1618-1687) was a prominent Baroque painter. He is particularly known for his religious works and his contributions to the art world of Seville.

In the realm of literature, Isidro Infante (1922-1996) was a Chilean poet and writer. He was a significant figure in the Latin American literary scene, known for his poetic works that explored themes of social injustice and the human condition.

Throughout history, the name Isidro has been carried by individuals from various walks of life, reflecting its enduring presence in the Spanish-speaking world and its roots in ancient Greek and Latin civilizations.